This study was designed to evaluate the bone formation capability of the bone substitute when compared with autogenic bone, freeze-dried demineralized allogeneic bone and bioglass into parietal bone of the rats. We made the parietal bone defects
in
7×7mm size rats and has performed the bone graft in each experimental groups. Postoperatively 1, 2, 4, 6, 8 weeks, each specimen stained with H & E, Masson's trichrome methods. We evaluated the osteogenesis capability in each groups.
@ES The result were as follow :
@EN 1. Inflammatory cell infiltration approached at 1 week and disappeared at 4 weeks in all experimental group, expecially severe in freeze-dried demineralized allogeneic bone group.
2. New capillry proliferation was increased in autogeneic bone graft group than any other groups and was increase till 2 weeks and decreased in freeze-dried demineralized allogeneic bone group and was few in bioglass group.
3. Osteoblastic activity increased in autogeneic bone and freeze-dried demineralized allogeneic bone groups till 4 weeks, and decreased in 6 weeks which no difference between these groups. But, few occurred in bioglass group till 6 weeks.
4. Initial osteoclastic activity was prominent in freeze-dried demineralized allogeneic bone group and few in autogeneic bone group.
5. New bone formation bega at 1 week in autograft and freeze-dried demineralized allogenic bone groups, but, mild new bone formation at 8 weeks in bioglass.
|